Description
Biochem/physiol Actions Neuroprotective in situations of hypoxia and ischemia; biosynthetic intermediate of membrane phospholipids; cerebral vasodilator; inhibits PLA2 activation.
Caution Hygroscopic
Properties
biological source from yeast
assay ~98%
form solid
color white
solubility H2O: 100 mg/mL
storage temp. −20°C
Safety
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany 3
References
reference Onal, et al., Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats. Stroke 28, 1060-1065, (1997) Abstract
Clark, et al., A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group. Neurology 49, 671-678, (1997) Abstract
Schabitz, et al., The effects of prolonged treatment with citicoline in temporary experimental focal ischemia. J. Neurol. Sci. 38, 21-25, (1996)
Merck Merck 13,2343
Beilstein Beil. 25,IV,3676
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